Theme Abstract
COST Action CM0701
Cascade Chemoenzymatic Processes – New Synergies Between Chemistry and Biochemistry
The main objective of the Action is to increase the innovative potential of biocatalysis by promoting the multistep catalytic concept, thus bringing this methodology closer to the application sphere.
The integration of biocatalysis into chemical processes is one of the three pillars (the pillar) of the European Platform on „Sustainable Chemistry“. This methodology also belongs to the fundamental strategies of „Green Chemistry“.
Therefore, this COST Action (acronym ) aims to enhance the synthetic potential of biocatalysis by coupling biotransformations one to another and integrating them with chemical steps to increase the product purity and yields close to quantitative values. A multidisciplinary approach is required to achieve this goal, involving precursor synthesis, enzyme screening, heterologous protein expression, enzyme mutagenesis, biocatalyst (co)-immobilization, bioreactor design and chiral product analysis.
CASCAT will consist of four Working Groups applying the multi-step approach to the synthesis/modification and transfer of glycosyl donors/acceptors, the deracemization of amino acids by multiple hydrolase systems, the synthesis of valuable amides and carboxylic acids from cheap chemicals (e.g. aldehydes) via combined action of enzymes involved in nitrile metabolism and entry or follow-up (chemo)enzymatic steps, the development of novel paths to biologically relevant chiral compounds using multienzyme-carboligation reactions or in situ cofactor regeneration.
This research will focus on the production of bioactive target molecules (e.g., non-natural amino-acids, glycoconjugates and mimetics, flavonoids, steroids) and chiral precursors of enantiopure pharmaceuticals.
- Keywords: Cascade reactions, Multistep enzymatic transformations, Biocatalysis, Industrial Biotechnology, Sustainable Chemistry.
- Domain: Chemistry and Molecular Sciences and Technologies
- Action title: Cascade Chemoenzymatic Processes – New Synergies Between Chemistry and Biochemistry
COST Actions
COST Action CM1407
COST Action FA1403
COST Action CM1307
COST Action CM1303
COST Action BM1203
COST Action CM1102
COST Action CM1003
COST Action CM1001
COST Action CM0804
COST Action CM0701
- Theme Abstract
- WG3 Meeting in Prague - 16th May 2009
- Official web page
COST Action CM0602
COST WG D34/0001/05
COST WG D28/0008/03
COST WG D25/0002/02
- Theme abstract
- Working group participants
- Kick-off meeting: October 19, 2002, University of Stuttgart
- Short term scientific missions
- Participation in D25 Workshops
- Meetings of the Working Group
- WG meeting: July 3, 2005, TU Delft (in conjunction with Biotrans 2005)
- WG meeting: April 18, 2006, Graz, Austria
- Final Report
COST WG D25/0001/01