Publications

• 2012 (6)
• 2011 (23)
• 2010 (27)
• 2009 (20)
• 2008 (17)
• 2007 (9)
• 2006 (14)
• 2005 (10)
• 2004 (13)
• 2003 (11)
• 2002 (5)
• Patents (13)

Publications 2012

• Heterologous Expression and Characterization of an N-Acetyl-β-Dhexosaminidase from Lactococcus lactis ssp. lactis IL1403

  H. A. Nguyen, T.-H. Nguyen, V. Křen, V. G. H. Eijsink, D. Haltrich, and C. K. Peterbauer

  Journal of Agricultural and Food Chemistry, 2012, 60, 3275−3281

• Chemo-enzymatic modification of poly-N-acetyllactosamine (LacNAc) oligomers and N,N-diacetyllactosamine (LacDiNAc) based on galactose oxidase treatment

  C. E. Kupper, R. R. Rosencrantz, B. Henßen, H. Pelantová, S. Thönes, A. Drozdová, V. Křen and L. Elling

  Beilstein J. Org. Chem., 2012, 8, 712–725

• Epoxide Hydrolases and their Applications in Organic Synthesis

  M. Kotik, A. Archelas and R. Wohlgemuth

  Current Organic Chemistry, 2012, 16, 451-482

• Influence of point mutations near the active site on the catalytic properties of fungal arylacetonitrilases from Aspergillus niger and Neurospora crassa

  A. Petříčková, O. Sosedov, S. Baum, A. Stolz, L. Martínková

  Journal of Molecular Catalysis B: Enzymatic, 2012, 77, 74 – 80

• Sequencing, cloning and high-yield expression of a fungal b-N-acetylhexosaminidase in Pichia pastoris

  K. Slámová, P. Bojarová, D. Gerstorferová, B. Fliedrová, J. Hofmeisterová, M. Fiala, P. Pompach, V. Křen

  Protein Expression and Purification, 2012, 82, 212–217

• Sequence diversity in haloalkane dehalogenases, as revealed by PCR using family-specific primers

  Michael Kotik, Veronika Faměrová

  Journal of Microbiological Methods, 2012, 88, 212–217

Publications 2011

• Facile production of Aspergillus niger a-N-acetylgalactosaminidase in yeast

  H. Mrázek, O. Benada, P. Man, O. Vaněk, V. Křen, K. Bezouška, L. Weignerová

  Protein Expression and Purification, 2011, 81, 106–114

• Synthesis and Antiangiogenic Activity of New Silybin Galloyl Esters

  R. Gažák, K. Valentová, K. Fuksová, P. Marhol, M. Kuzma, M. A. Medina, I. Oborná, J. Ulrichová, and V. Křen

  J. Med. Chem, 2011, 54, 7397–7407

• Laboratory evolution of an epoxide hydrolase – Towards an enantioconvergent biocatalyst

  M. Kotik, A. Archelas, V. Faměrová, P. Oubrechtová, V. Křen

  Journal of Biotechnology, 2011, 156, 1 – 10

• Electrochemical investigation of flavonolignans and study of their interactions with DNA in the presence of Cu(II)

  M. Zatloukalová, V. Křen, R. Gažák, M. Kubala, P. Trouillas, J. Ulrichová, J. Vacek

  Bioelectrochemistry, 2011, 82, 117–124

• Biodegradation of tetrabromobisphenol A by oxidases in basidiomycetous fungi and estrogenic activity of the biotransformation products

  B. Uhnáková, R. Ludwig, J. Pěknicová, L. Homolka, L. Lisá, M. Šulc, A. Petříčková, F. Elzeinová, H. Pelantová, D. Monti, V. Křen, D. Haltrich, L. Martínková

  Bioresource Technology, 2011, 102, 9409–9415

• Combinatorial One-Pot Synthesis of Poly-N-acetyllactosamine Oligosaccharides with Leloir-Glycosyltransferases

  C. Rech, R. R. Rosencrantz, K. Křenek, H. Pelantova, P. Bojarova, C. E. Romer, F.-G. Hanisch, V. Křen, L. Elling

  Adv. Synth. Catal., 2011, 353, 2492 – 2500

• Charged Hexosaminides as New Substrates for b-N-Acetylhexosaminidase-Catalyzed Synthesis of Immunomodulatory Disaccharides

  P. Bojarová, K. Slámová, K. Křenek, R. Gažák, N. Kulik, R. Ettrich, H. Pelantová, M. Kuzma, S. Riva, D. Adámek, K. Bezouška, V. Křen

  Adv. Synth. Catal., 2011, 353, 2409 – 2420

• Glycosidases in Synthesis of Glycomimetics and Unnatural Carbohydrates

  V. Křen

  Synthesis and Biological Applications of Glycoconjugates, 2011, chapter (p. 226-239), Editor: Olivier Renaudet & Nicolas Spinelli

• Narrow-bore core–shell particles and monolithic columns in the analysis of silybin diastereoisomers

  P. Marhol, R. Gažák, P. Bednář, V. Křen

  J. Sep. Sci., 2011, 34, 2206–2213

• Evidence for differences in regioselective and stereoselective glucuronidation of silybin diastereomers from milk thistle (Silybum marianum) by human UDPglucuronosyltransferases

  P. Jančová, M. Šiller, E. Anzenbacherová, V. Křen, P. Anzenbacher and V. Šimánek

  Xenobiotica, 2011, 1-9

• Computational Modelling of Catalytic Properties and Modified Substrates of Fungal b-N-Acetylhexosaminidases

  N. Kulik and K. Slámová

  Mini-Reviews in Organic Chemistry, 2011, 8, 270-280

• Enzymatic characterization and molecular modeling of an evolutionarily interesting fungal b-N-acetylhexosaminidase

  H. Ryšlavá, A. Kalendová, V. Doubnerová, P. Skočdopol, V. Kumar, Z. Kukačka, P. Pompach, O. Vaněk, K. Slámová, P. Bojarová, N. Kulík, R. Ettrich, V. Křen and Karel Bezouška

  FEBS Journal, 2011, 278, 2469–2484

• Enzymatic synthesis of dimeric glycomimetic ligands of NK cell activation receptors

  A. Drozdová, P. Bojarová, K. Křenek, L. Weignerová, B. Henßen, L. Elling, H. Christensen, H. H. Jensen, H. Pelantová, M. Kuzma, K. Bezouška, M. Krupová, D. Adámek, K. Slámová a, V. Křen

  Carbohydrate Research, 2011, 346, 1599–1609

• High-yield continuous production of nicotinic acid via nitrile hydratase–amidase cascade reactions using cascade CSMRs

  L. Cantarella, A. Gallifuoco, A. Malandra, L. Martínková, A. Spera, M. Cantarella

  Enzyme and Microbial Technology, 2011, 48, 345–350

• Regioselective alcoholysis of silybin A and B acetates with lipases

  K. Purchartová, P. Marhol, R. Gažák, D. Monti, S. Riva, M. Kuzma, V. Křen

  Journal of Molecular Catalysis B: Enzymatic, 2011, 71, 119–123

• On the Reduction of NC Chelated Organoantimony(III) Chlorides

  L Dostál, R. Jambor, A. Růžička, and P. Šimon

  Eur. J. Inorg. Chem., 2011, 2380-2386

• Biotransformation of nitriles to hydroxamic acids via a nitrile hydratase–amidase cascade reaction

  V. Vejvoda, L. Martínková, A. B. Veselá, O. Kaplan, S. Lutz-Wahl, L. Fischer, B. Uhnáková

  Journal of Molecular Catalysis B: Enzymatic, 2011, 71, 51–55

• Dimerisation Process of Silybin-Type Flavonolignans: Insights from Theory

  P. Košinová, R. Gažák, J.-L. Duroux, R. Lazzaroni, V. Křen, X. Assfeld and P. Trouillas

  ChemPhysChem, 2011, 12, 1135 – 1142

• Glycosidases in Carbohydrate Synthesis: When Organic Chemistry Falls Short

  P. Bojarová and V. Křen

  Chimia, 2011, 65, 65–70

• Dendri-RAFTs: a second generation of cyclopeptide-based glycoclusters

  I. Bossu, M. Šulc, K. Křenek, E. Dufour, J. Garcia, N. Berthet, P. Dumy, V. Křen and O. Renaudet

  Org. Biomol. Chem., 2011, 9, 1948

• Production, enrichment and immobilization of a metagenome-derived epoxide hydrolase

  M. Grulich, J. Marsalek, P. Kyslíka, V. Stepanek, M. Kotik

  Process Biochemistry, 2011, 46, 526–532

• Heterologous expression, purification and characterization of nitrilase from Aspergillus niger K10

  O. Kaplan, K. Bezouška, O. Plíhal, R. Ettrich, N. Kulik, O. Vaněk, D. Kavan, O. Benada, A. Malandra, O. Šveda, A. B. Veselá, A. Rinágelová, K. Slámová, M. Cantarella, J. Felsberg, J. Dušková, J. Dohnálek, M. Kotik, V. Křen, L. Martínková

  BMC Biotechnology, 2011, 11:2

• Genome mining for the discovery of new nitrilases in filamentous fungi

  O. Kaplan, K. Bezouška, A. Malandra, A.B. Veselá, A. Petříčková, J. Felsberg, A. Rinágelová, V. Křen, L. Martínková

  Biotechnol. Lett., 2011, 33:309–312

Publications 2010

• Catabolism of Nitriles in Rhodococcus

  L. Martínková, M. Pátek, A. B. Veselá, O. Kaplan, B. Uhnáková, Jan Nešvera

  Biology of Rhodococcus, 2010, chapter (p. 171-206), Editor: Hector M. Alvarez

• Dehydrosilybin attenuates the production of ROS in rat cardiomyocyte mitochondria with an uncoupler-like mechanism

  E. Gabrielová, M. Jabůrek, R. Gažák, J. Vostálová, J. Ježek, V. Křen, M. Modrianský

  J. Bioenerg Biomembr, 2010, 42:499–509

• Synthesis and Evaluation of Biological Activity of the Quaternary Ammonium Salts of Lupane-, Oleanane-, and Ursane-Type Acids

  David Biedermann, Barbara Eignerova, Marian Hajduch, Jan Sarek

  Synthesis, 2010, 22, 3839–3848

• A novel chemo-multienzymatic synthesis of bioactive cyclophellitol and epi-cyclophellitol in both enantiopure forms

  N. D’Antona, R. Morrone, P. Bovicelli, G. Gambera, D. Kubáč, L. Martínková

  Tetrahedron: Asymmetry, 2010, 21, 2448–2454

• The α-galactosidase type A gene aglA from Aspergillus niger encodes a fully functional α-N-acetylgalactosaminidase

  Natallia Kulík, Lenka Weignerová, Tomáš Filipi, Petr Pompach, Petr Novák, Hynek Mrázek, Kristýna Slámová, Karel Bezouška, Vladimír Křen, and Rüdiger Ettrich

  Glycobiology, 2010, 20 (11), 1410–1419

• Azido leaving group in enzymatic synthesis - small and efficient

  P. Bojarová, V. Křen

  Carbohydrate chemistry. Chemical and Biological Approaches, 2010, RSC Publishing, Cambridge, UK, 36, 310-332

• Large-scale separation of silybin diastereoisomers using lipases

  R. Gažák, P. Marhol, K. Purchartová, D. Monti, D. Biedermann, S. Riva, L. Cvak, V. Křen

  Process Biochemistry, 2010, 45, 1657–1663

• Analysis of anthocyanin pigments in Lonicera (Caerulea) extracts using chromatographic fractionation followed by microcolumn liquid chromatography - hybrid quadrupole time-of-flight mass spectrometer -mass spectrometry

  Renáta Myjavcová, Petr Marhol, Vladimír Křen, Vilém Šimánek, Jitka Ulrichová, Irena Palíková, Barbora Papoušková, Karel Lemr, Petr Bednář

  Journal of Chromatography A, 2010, 1217, 7932–7941

• Synthetic N-Acetyl-D-glucosamine Based Fully Branched Tetrasaccharide, a Mimetic of the Endogenous Ligand for CD69, Activates CD69+ Killer Lymphocytes upon Dimerization via a Hydrophilic Flexible Linker

  Kovalová A., Ledvina M., Šaman D., Zyka D., Kubíčková M., Žídek L., Sklenář V., Pompach P., Kavan D., Bílý J., Vaněk O., Kubínková Z., Libigerová M., Ivanová L., Antolíková M., Mrázek H., Rozbeský D., Hofbauerová K., Křen V., Bezouš

  Journal of Medicinal Chemistry, 2010, 53 (10), 4050-4065

• Cooperation between Subunits Is Essential for High-Affinity Binding of N-Acetyl-D-hexosamines to Dimeric Soluble and Dimeric Cellular Forms of Human CD69

  Kavan D., Kubíčková M., Bílý J., Vaněk O., Hofbauerová K., Mrázek H., Rozbeský D., Bojarová P., Křen V., Žídek L., Sklenář V., Bezouška K.

  Biochemistry, 2010, 49 (19), 4060-4067

• Synthesis of multivalent glycoconjugates containing the immunoactive LELTE peptide: Effect of glycosylation on cellular activation and natural killing by human peripheral blood mononuclear cells

  Renaudet O., Křenek K., Bossu I., Dumy P., Kádek A., Adámek D., Vaněk O., Kavan D., Gažák R., Šulc M., Bezouška K., Křen V.

  Journal of American Chemical Society, 2010, 132 (19), 6800-6808

• β-N-Acetylhexosaminidase: What‘s in a name...?

  K. Slámová, P. Bojarová, L. Petrásková, V. Křen

  Biotech. Adv., 2010, 28, 682–693

• Deoxynojirimycin and its hexosaminyl derivatives bind to natural killer cells receptors rNKR- P1A and hCD69

  G. Catelani, F. D’Andrea, A. Griselli, L. Guazzelli, P. Němcová, K. Bezouška, K. Křenek, V. Křen

  Bioorg. Med. Chem. Lett., 2010, 20, 4645-4648

• Synthesis and biological activity of glycosyl-1H-1,2,3-triazoles

  K. Slámová, P. Marhol, K. Bezouška, L. Lindkvist, S. G. Hansen, V. Křen*, H. H. Jensen

  Bioorg. Med. Chem. Lett., 2010, 20, 4263–4265

• 4-Deoxy-substrates for β-N-acetylhexosaminidases: How to make use of its loose specificity

  K. Slámová, R. Gažák, P. Bojarová, N. Kulik, R. Ettrich, H. Pelantová, P. Sedmera, V. Křen

  Glycobiology, 2010, 20 (8), 1002–1009

• Application of continuous stirred membrane reactor to 3-cyanopyridine bioconversion using the nitrile hydratase-amidase cascade system of Microbacterium imperiale CBS

  Cantarella L., Gallifuoco A., Malandra A., Martínková L., Pasquarelli F., Spera A., Cantarella M.

  Enzyme Microb. Technol., 2010, 47 (2010) 64–70

• Synthesis of novel cyano-cyclitols and their stereoselective biotransformation catalyzed by Rhodococcus erythropolis A4

  D’Antona N., Nicolosi G., Morrone R., Kubáč D., Kaplan O., Martínková L.

  Tetrahedron: Asymmetry, 2010, 21, 695-702

• Hydrolysis of benzonitrile herbicides by soil actinobacteria and metabolite toxicity

  Veselá A.B., Franc M., Pelantová H., Kubáč D., Vejvoda V., Šulce M:, Bhalla T.C., Macková M., Lovecká P., Janů P., Demnerová K., Martínková L.

  Biodegradation, 2010, 21 (5), 761-770

• Purification and characterization of nitrilase from Fusarium solani IMI196840

  Vejvoda V., Kubáč D., Davidová A., Kaplan O., Šulc M., Šveda O., Martínková L.

  Proc. Biochem., 2010, 45, 1115–1120

• Enzymatic Kinetic Resolution of Silybin Diastereoisomers

  D. Monti, R. Gažák, P. Marhol, D. Biedermann, K. Purchartová, M. Fedrigo, S. Riva, V. Křen

  J. Nat. Prod., 2010, 73 (4), 613-619

• Enzymatic processing of bioactive glycosides from natural sources

  L. Weignerová, V. Křen

  Topics Curr. Chem., 2010, 295/2010, 121-146, DOI: 10.1007/128_2010_51

• Biotransformations with nitrilases

  L. Martínková, V. Křen

  Curr. Opin. Chem. Biol., 2010, 14 (2), 130-137

• Condensation reactions catalyzed by α-N-acetylgalactosaminidase from Aspergillus niger yielding α-N-acetylgalactosaminides

  Weignerová L., Pelantová H., Manglová D., Michálková K., Křen V.

  Biocatalysis and Biotransformation, 2010, 28(2), 150-155

• Antioxidant and antiviral activities of silybin fatty acid conjugates

  Gažák R., Purchartová K., Marhol P., Živná L., Sedmera P., Valentová K., Kato N., Matsumura H., Kaihatsu K., Křen V.

  European Journal of Medicinal Chemistry, 2010, 45, 1059-1067

• Carboxylated calixarenes bind strongly to CD69 and protect CD69+ killer cells from suicidal cell death induced by tumor cell surface ligands

  Bezouška K., Šnajdrová R., Křenek K., Vančurová M., Kádek A., Adámek D., Lhoták P., Kavan D., Hofbauerová K., Man P., Bojarová P., Křen V.

  Bioorganic and Medicinal Chemistry, 2010, 18 (4), 1434-1440

• Reply to Erratum, Silybin (Silibinin) Structure and Chirality

  Křen V., Gažák R., Biedermann D., Marhol P.

  Chromatographia, 2010, 71 (1-2), 171

• Silybin (Silibinin) Structure and Chirality.

  Křen V., Gažák R., Biedermann D., Marhol P.

  Chromatographia, 2010, 71 (1-2), 167-168

Publications 2009

• Glycosyl Azides: Novel Substrates for Enzymatic Transglycosylations

  Křen V., Bojarová P.

  Practical Methods for Biocatalysis and Biotransformations, 2009, A John Wiley and Sons, Ltd., Publication, Chippenham, Wiltshire, UK, 232-235

• Glycosidases in synthesis

  Weignerová L., Bojarová P., Křen V.

  Carbohydrate chemistry. Chemical and Biological Approaches, 2009, RSC Publishing, Cambridge, UK, 35, 310-332

• UF-membrane Bioreactors for Kinetics Characterization of Nitrile Hydratase-Amidase-catalyzed Reactions: a Short Survey

  Cantarella M., Gallifuoco A., Spera A., Cantarella L., Kaplan O., Martínková L.

  Modern Biocatalysis, 2009, Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim, Germany, 273-285

• Nitrilases from Filamentous Fungi

  Martínková L., Vejvoda V., Kaplan O., Křen V., Bezouška K., Cantarella M.

  Modern Biocatalysis, 2009, Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim, Germany, 229-244

• The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine.

  J. Křížková, K. Burdová, M. Stiborová, V. Křen, P. Hodek

  Interdisc Toxicol., 2009, 2 (3), 201-204

• Continuous hydrolysis of 4-cyanopyridine by nitrilases from Fusarium solani O1 and Aspergillus niger K10

  A. Malandra, M. Cantarella, O. Kaplan, V. Vejvoda, B. Uhnáková, B. Štěpánková, D. Kubáč, L. Martínková

  Appl. Microbiol. Biotechnol., 2009, 85 (2), 277-284

• Biodegradation of brominated aromatics by cultures and laccase of Trametes versicolor

  B. Uhnáková, A. Petříčková, D. Biedermann, L. Homolka, V. Vejvoda, P. Bednář, B. Papoušková, M. Šulc, L. Martínková

  Chemosphere, 2009, 76 (6), 826-832

• Silibinin chirality

  V. Křen

  J. Photochem. Photobiol. A: Chemistry, 2009, 203 (2-3), 222-223

• Chemoenzymatic preparative separation of silybins A and B

  Vladimír Křen, Radek Gažák, Kateřina Purchartová, Petr Marhol, David Biedermann, Petr Sedmera

  Journal of Molecular Catalysis B: Enzymatic, 2009, 61, 247-251

• Biocatalytic application of nitrilases from Fusarium solani O1 and Aspergillus niger K10

  Margit Winkler, Ondřej Kaplan, Vojtěch Vejvoda, Norbert Klempier, Ludmila Martínková

  Journal of Molecular Catalysis B: Enzymatic, 2009, 59, 243–247

• Fungal nitrilases as biocatalysts: Recent developments

  L. Martínková, V. Vejvoda, O. Kaplan, D. Kubáč, A. Malandra, M. Cantarella, K. Bezouška, V. Křen

  Biotechnology Advances, 2009, 27, 661-670

• Aryl sulfamates are broad spectrum inactivators of sulfatases: Effects on sulfatases from various sources

  Pavla Bojarová, Spencer J. Williams

  Bioorganic & Medicinal Chemistry Letters, 2009, 19, 477–480

• Synthesis of LacdiNAc-terminated glycoconjugates by mutant galactosyltransferase – way to new glycodrugs and materials

  P. Bojarová, K. Křenek, K. Wetjen, K. Adamiak, H. Pelantová, K. Bezouška, L. Elling, V Křen

  Glycobiology, 2009, 19 (5), 509–517

• Glycosidases: a key to tailored carbohydrates

  P. Bojarová, V. Křen

  Trends in Biotechnology, 2009, 27 (4), 199 - 209

• Synthesis of sulfated glucosaminides and use in studying the substrate specificity of sulfatases and fungal β-N-acetylhexosaminidases

  K. J. Loft, P. Bojarová, K. Slámová, V. Křen, S. J. Williams

  ChemBioChem, 2009, 10, 565 – 576

• Molecular mechanisms of silybin and 2,3-dehydrosilybin antiradical activity - role of individual hydroxyl groups

  R. Gažák, P. Sedmera, M. Vrbacký, J. Vostálová, Z. Drahota, P. Marhol, D. Walterová, V. Křen

  Free Rad. Biol. Med., 2009, 46, 745–758

• Biodegradation potential of the genus Rhodococcus

  L. Martínková, B. Uhnáková, M. Pátek, J. Nešvera, V. Křen

  Environment International, 2009, 35, 162-177

• Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquids media and evaluation of their anti-tumor proliferative activity

  E. Theodosiou, M. H. Katsoura, H. Loutrari, K. Purchartová, V. Křen, F. N. Kolisis, H. Stamatis

  Biocat. Biotrans., 2009, 27(3), 161 - 169

• α-Galactosidases and their applications in biotransformations

  L. Weignerová, P. Simerská, V. Křen

  Biocatalysis and Biotransformation, 2009, 27(2): 79

• Chemo-enzymatic synthesis of poly-N-Acetyllactosamine (poly-LacNAc) structures and their characterization for galectin-mediated binding of ECM glycoproteins to biomaterial surfaces

  B. Sauerzapfe, K. Křenek, J. Schmiedel, W. W. Wakarchuk, H. Pelantová, V. Křen, L. Elling

  Glycoconjugates Journal, 2009, 26:141–159

Publications 2008

• Direct evidence for ArO-S bond cleavage upon inactivation of Pseudomonas aeruginosa arylsulfatase by aryl sulfamates

  Bojarová P., Denehy E., Walker I., Loft K., De Souza D.P., Woo L.W.L., Potter B.V.L., Mc Conville M.J., Williams S.J.

  ChemBioChem, 2008, 9, 613-623

• Nitrile hydratase CLEAs: The immobilization and stabilization of an industrially important enzyme

  Sander van Pelt, Sandrine Quignard, David Kubáč, Dimitry Y. Sorokin, Fred van Rantwijk and Roger A. Sheldon

  Green Chem., 2008, 10, 395–400

• Sulfotransferases, sulfatases and formylglycine-generating enzymes: a sulfation fascination

  Pavla Bojarová and Spencer J. Williams

  Current Opinion in Chemical Biology, 2008, 12:573–581

• Glycoside vs. aglycon “The role of glycosidic residue in biological activity”

  V. Křen, Fraser-Reid (editor)

  Glycoscience, 2008, Springer, chapter (56 pp)

• Constituents and Antimicrobial Properties of Blue Honeysuckle, a Novel Source for Phenolic Antioxidants

  Palíková I., Heinrich J., Bednár P., Marhol P., Křen V., Cvak L., Valentová K., Ruzicka Filip, Holá V., Kolár M., Simánek V., Ulrichová J.

  J. Agric. Food Chem., 2008, 56 (24), 11883-11889

• Sweet antibiotics - the role of glycosidic residues in antibiotic and antitumor activity and their randomization

  V. Křen, T. Řezanka

  FEMS Microbiol. Reviews, 2008, 32(5), 858-889

• Induction, purification and characterization of a α-N-acetylgalactosaminidase from Aspergillus niger

  L. Weignerová, T. Filipi, D. Manglová, V. Křen

  Applied Microbiology and Biotechnology, 2008, 79, 769-774

• Improved Preparation of β-D-ManNAc-(1→4)-D-Glc and β-D-TalLNAc-(1→4)-D-GLC Disaccharides and Evaluation of their Activating Properties on the Natural Killer Cells NKR-P1 and CD69 Receptors

  E. Attolino, F. Bonaccorsi, G. Catelani, F. D'Andrea, K. Křenek, K. Bezouška, V. Křen

  J. Carb. Chem, 2008, 27, 156 - 171

• Amidase-catalyzed production of nicotinic acid in batch and continuous stirred membrane reactors

  M. Cantarella, L. Cantarella, A. Gallifuoco, R. Intellini, O. Kaplan, A. Spera and L. Martínková

  Enzyme and Microbial Technology, 2008, 42 (3), 222-229

• Purification and characterization of a nitrilase from Fusarium solani O1

  V. Vejvoda, O. Kaplan, K. Bezouška, P. Pompach, M. Šulc, M. Cantarella, O. Benada, B. Uhnáková, A. Rinágelová, S. Lutz-Wahl, L. Fischer, V. Křen and L. Martínková

  J. Mol. Catal./B Enzymatic, 2008, 50 (2-4), 99-106

• Biotransformation of nitriles to amides using soluble and immobilized nitrile hydratase from Rhodococcus erythropolis A4

  D. Kubáč, O. Kaplan, V. Elišáková, M. Pátek, V. Vejvoda, K. Slámová, A. Tóthová, M. Lemaire, E. Gallienne, S. Lutz-Wahl, L. Fischer, M. Kuzma, H. Pelantová, S. van Pelt, J. Bolte, V. Křen and L. Martínková

  J. Mol. Catal./B Enzymatic, 2008, 50 (2-4), 107-113

• Selection and screening for enzymes of nitrile metabolism

  L. Martínkova, V. Vejvoda and V. Křen

  Journal of Biotechnology, 2008, 133 (3), 318-326

• Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: In vivo safety assessment

  K. Valentová, D. Stejskal, J. Barteka, S. Dvořáčková, V. Křen, J. Ulrichová and V. Šimánek

  Food and Chemical Toxicology, 2008, 46(3), 1006-1013

• Mechanism of the Antioxidant Action of Silybin and 2,3-Dehydrosilybin Flavonolignans: A Joint Experimental and Theoretical Study

  P. Trouillas, P. Marsal, A. Svobodová, J. Vostálová, R. Gažák, J. Hrbáč, P. Sedmera, V. Křen, R. Lazzaroni, J.-L. Duroux and D. Walterova

  J. Phys. Chem. A, 2008, 112, 1054-1063

• Characterization of recombinant fusion constructs of human β1,4-galactosyltransferase 1 and the lipase pre-propeptide from Staphylococcus hyicus

  Sauerzapfe, D.-J. Namdjou, T. Schumacher, N. Linden, K. Křenek, V. Křen, L. Elling

  J. Mol. Catal./B Enzymatic., 2008, 50 (2-4), 128-140

• N-Acetylhexosamine triad in one molecule: Chemoenzymatic introduction of 2-acetamido-2-deoxy-β-D-galactopyranosyluronic acid residue into a complex oligosaccharide

  P. Bojarová, K. Křenek, M. Kuzma, L. Petrásková, K. Bezouška, D.-J. Namdjou, L. Elling, V. Křen

  J. Mol. Catal./B Enzymatic., 2008, 50 (2-4), 69-73

• Laccase-mediated dimerization of the flavonolignan silybin

  R. Gažák, P. Sedmera, M. Marzorati, S. Riva, V. Křen

  J. Mol. Catal./B Enzymatic, 2008, 50, 87-92

Publications 2007

• Studies on oxidation of ergot alkaloids: oxidation and desaturation of dihydrolysergol-stereochemical requirements

  Radek Gažák, Vladimír Křen, Petr Sedmera, Daniele Passarella, Michaela Novotná and Bruno Danieli

  Tetrahedron, 2007, 60, 10466–10478

• Structure of the dimeric N-glycosylated form of fungal β-N-acetylhexosaminidase revealed by computer modeling, vibrational spectroscopy, and biochemical studies

  Rüdiger Ettrich, Vladimír Kopecký Jr., Kateřina Hofbauerová, Vladimír Baumruk, Petr Novák, Petr Pompach, Petr Man, Ondřej Plíhal, Michal Kutý, Natallia Kulik, Jan Sklenář, Helena Ryšlavá, Vladimír Křen and Karel Bezouška

  BMC Structural Biology, 2007, 7:32

• N-Acetyl-D-glucosamine substituted calix[4]arenes as stimulators of NK cell-mediated antitumor immune response

  Karel Křenek, Markéta Kuldová, Katarína Hulíková, Ivan Stibor, Pavel Lhoták, Miroslav Dudič, Jan Budka, Helena Pelantová, Karel Bezouška, Anna Fišerová and Vladimír Křen

  Carbohydrate Research, 2007, 342, 1781-1792

• Biotransformation of heterocyclic dinitriles by Rhodococcus erythropolis and fungal nitrilases

  Vojtěch Vejvoda, Ondřej Šveda, Ondřej Kaplan, Věra Přikrylová, Veronika Elišáková, Michal Himl, David Kubáč, Helena Pelantová, Marek Kuzma, Vladimír Křen & Ludmila Martínková

  Biotechnol. Lett., 2007, 29, 1119-1124

• Glycosyl Azides – An Alternative Way to Disaccharides

  Pavla Bojarová, Lucie Petrásková, Erica Ferrandi, Daniela Monti, Helena Pelantová, Marek Kuzma, Pavla Simerská, and Vladimír Křen

  Adv. Synth. Catal., 2007, 349 (8-9), 1514 - 1520

• Enzymatic approaches to O-glycoside introduction: Glycosidases

  P. Fialová, V. Křen

  Comprehensive Glycoscience, 2007, (J. P. Kamerling, Ed.); Elsevier: Oxford, 453-487

• Silybin and silymarin – new and emerging applications in medicine

  R. Gažák, D. Walterová, V. Křen

  Curr. Med. Chem., 2007, 2007, 14 (3), 315 - 338

• Large propeptides of fungal β-N-acetylhexosaminidases are novel enzyme regulators that must be processed intracellularly to control activity, dimerization, and secretion into the extracellular environment

  O. Plíhal, J. Sklenář, K. Hofbauerová, P. Novák, P. Man, P. Pompach, H. Ryšlavá, A. Charvátová-Pišvejcová, V. Křen, K. Bezouška

  Biochemistry, 2007, 46, 2719-2734

• Induction and characterization of an unusual α-D-galactosidase from Talaromyces flavus

  Pavla Simerská, Daniela Monti, Ivana Čechová, Helena Pelantová, Martina Macková, Karel Bezouška, Sergio Riva, Vladimír Křen

  J. Biotechnol., 2007, 128(1), 61-71

Publications 2006

• Immobilization of fungal nitrilase and bacterial amidase – two enzymes working in accord

  Vejvoda V., Kaplan O., Kubáč D., Křen V., Martínková L.

  Biocatal. Biotrans., 2006, 24, 414-418

• Extension of the Nef reaction to C-glycosylnitromethanes

  Mária Petrušová, Michal Vojtech, Božena Pribulová, Erika Lattová, Mária Matulová, Monika Poláková, James N. BeMiller, Vladimír Křen and Ladislav Petruš

  Carbohydrate Research, 2006, 341, 2019-2025

• Preparative production and separation of 2-acetamido-2-deoxymannopyranoside-containing saccharides using borate-saturated polyolic exclusion gels

  Lucie Petrásková, Andrea Charvátová, Věra Přikrylová, Veronika Kristová, Jana Rauvolfová, Ludmila Martínková, Jesus Jiménez-Barbero, Nuria Aboitiz, Ladislav Petruš, Vladimír Křen

  J. Chromatogr. A, 2006, 1127, 126-136

• Mild hydrolysis of nitriles by Fusarium solani strain O1

  Vejvoda V., Kaplan O., Klozová J., Masák J., Čejková A., Jirků V., Stloukal R., Martínková L

  Folia Microbiol., 2006, 73, 567-575

• Purification and characterization of a nitrilase from Aspergillus niger K10

  Kaplan O., Vejvoda V., Plíhal O., Pompach P., Kavan D., Fialová P., Bezouška K., Macková M., Cantarella M., Jirků V., Křen V., Martínková L.

  Appl. Microbiol. Biotechnol, 2006,

• Hyperinduction of nitrilases in filamentous fungi

  Kaplan O., Vejvoda V., Charvátová-Pišvejcová A., Martínková L.

  J. Ind. Microbiol. Biotechnol., 2006, 33, 891-896

• New derivatives of silybin and 2,3-dehydrosilybin and their cytotoxic and P-glycoprotein modulatory activity

  Petr Džubák,
  Marián Hajdúch,
  Radek Gažák, Alena Svobodová, Jitka Psotová, Daniela Walterová, Petr Sedmera and Vladimír Křen

  Bioorganic & Medicinal Chemistry, 2006, 14 (11) 3793-3810

• Biotransformation of nitriles by Rhodococcus equi A4 immobilized in LentiKats®

  David Kubáč, Alena Čejková, Jan Masák, Vladimír Jirků, Marielle Lemaire Estelle Gallienne, Jean Bolte, Radek Stloukal, Ludmila Martínková

  Journal of Molecular Catalysis B: Enzymatic, 2006, 39, 59–61

• Mild hydrolysis of nitriles by the immobilized nitrilase from Aspergillus niger K10

  Vojtěch Vejvoda, Ondřej Kaplan, Karel Bezouška, Ludmila Martínková

  Journal of Molecular Catalysis B: Enzymatic, 2006, 39, 55–58

• The in vitro biological activity of Lepidium meyenii extracts

  K. Valentová, D. Buckiová, V. Křen, J. Pěknicová, J. Ulrichová and V. Šimánek

  Cell Biol Toxicol, 2006, 22, 91–99

• β-1,4-Galactosyltransferase-catalyzed glycosylation of sugar derivatives: Modulation of the enzyme activity by α-lactalbumin, immobilization and solvent tolerance

  Andrea Pišvejcová, Cristina Rossi, Lucie Hušáková, Vladimír Křen, Sergio Riva, Daniela Monti

  Journal of Molecular Catalysis B: Enzymatic, 2006, 39, 98–104

• Cyanodeoxy-Glycosyl Derivatives as Substrates for Enzymatic Reactions

  Ana T. Carmona, Pavla Fialová, Vladimir Křen, Rudiger Ettrich, Ludmila Martínková, Antonio J. Moreno-Vargas, Cristina González, andInmaculada Robina

  Eur. J. Org. Chem., 2006, 1876–1885

• Unique transglycosylation potential of extracellular α-D-galactosidase from Talaromyces flavus

  Pavla Simerská, Marek Kuzma, Daniela Monti, Sergio Riva,Martina Macková, Vladimír Křen

  Journal of Molecular Catalysis B: Enzymatic, 2006, 39, 128–134

• Hydrolysis of nitriles and amides by filamentous fungi

  Ondřej Kaplan, Konstantia Nikolaou, Andrea Pišvejcová, Ludmila Martínková

  Enzyme and Microbial Technology, 2006, 38, 260–264

Publications 2005

• Glycosyl azide - a novel substrate for enzymatic transglycosylations

  Pavla Fialová, Ana T. Carmona, Inmaculada Robina, Rudiger Ettrich, Petr Sedmera

  Tetrahedron Letters, 2005, 46, 8715–8718

• Biocatalyzed Generation of Molecular Diversity: Selective Modification of the Saponin Asiaticoside

  Daniela Monti, Andrea Candido, M. Manuel Cruz Silva, Vladimír Křen,Sergio Riva, Bruno Danieli

  Adv. Synth. Catal., 2005, 347, 1168 – 1174

• Synthesis and microbial transformation of β-amino nitriles

  Margit Winkler, Ludmila Martínková, Astrid C. Knall, Stefan Krahulec and Norbert Klempier

  Tetrahedron, 2005, 61, 4249–4260

• Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation

  Martina Plíšková, Jan Vondráček, Vladimír Křen, Radek Gažák, Petr Sedmera, Daniela Walterová, Jitka Psotová, Vilím Šimánek, Miroslav Machala

  Toxicology, 2005, 215, 80–89

• The Efficiancy of Glucosamine and Chondroitin Sulfate In the Tretment of Osteoarthritis: Are These Saccharides Drugs or Nutraceuticals?

  Vilím Šimánek, Vladimír Křen, Jitka Ulrichová, Jiří Galloc

  Biomed. Papers, 2005, 149(1), 51–56

• Silybin and Silimarin – New Efects And Applictions

  Vladimír Křen, Daniela Walterová

  Biomed. Papers, 2005, 149(1), 29–41

• Glycosyl azide - a novel substrate for enzymatic transglycosylations

  Pavla Fialová, Ana T. Carmona, Inmaculada Robina, Rudiger Ettrich, Petr Sedmera, Věra Přikrylová, Lucie Petrásková-Hušáková and Vladimír Křen

  Tetrahedron Letters, 2005, 46, 8715-8718

• Biocatalyzed Generation of Molecular Diversity: Selective Modification of the Saponin Asiaticoside

  Daniela Monti, Andrea Candido, M. Manuel Cruz Silva, Vladimir Křen, Sergion Riva, Bruno Danieli

  Adv. Synth. Catal., 2005, 347, 1168 – 1174

• A chemoenzymatic route to mannosamine derivatives bearing different N-acyl groups

  Veronika Kristová, Ludmila Martínková, Lucie Hušáková, Marek Kuzma, Jana Rauvolfová, Daniel Kavan, Petr Pompach, Karel Bezouška, Vladimír Křen

  Journal of Biotechnology, 2005, 115, 157–166

• Combined Application of Galactose Oxidase and β-N-Acetylhexosaminidase in the Synthesis of Complex Immunoactive N-Acetyl-D-galactosaminides

  Pavla Fialova, Darius-Jean Namdjou, Rudiger Ettrich, Vera Prikrylova, Jana Rauvolfova, Karel Krenek, Marek Kuzma, Lothar Elling, Karel Bezouska, Vladimr Kren

  Adv. Synth. Catal., 2005, 347 (7-8), 997–1006

Publications 2004

• Hydrolytic and transglycosylation reactions of N-acyl modified substrates catalysed by β-N-acetylhexosaminidases

  P. Fialová, L. Weignerová, J. Rauvolfová, V. Přikrylová, A. Pišvejcová, R. Ettrich, M. Kuzma, P. Sedmera, V. Křen

  Tetrahedron, 2004, 60, 693–701

• Pergolide, Terguride and N,N'-spacer-linked Oligomers of Both Interact with 5-HT2A Receptors of Rat Tail Artery

  V. Křen, E. Eich, H. H. Pertz

  Physiol. Res., 2004, 53, 35-43

• In vitro antiplasmodial activities of semisynthetic N,N'-spacer-linked oligomeric ergolines

  Kristina Jenett-Siems, Inga Köhler, Carola Kraft, Heinz H. Pertz, Vladimr Křen, Anna Fišerová, Marek Kuzma, Jitka Ulrichová , Ulrich Bienzle and Eckart Eich

  Bioorganic & Medicinal Chemistry, 2004, 12 (4), 817–824

• Screening and Characterization of β-N-Acetylhexosaminidasesfor the Synthesis of Nucleotide-Activated Disaccharides

  Veronika Nieder, Michael Kutzer, Vladimir Kren, Ricardo Gutiérrez Gallego, Johannis P. Kamerling, Johannes F.G. Vliegenthart, Lothar Elling

  Enz. Microb. Technol., 2004, 34, 407–414

• Fluorescent Labelled Thiourea-bridged Glycodendrons

  Krist P., Vannucci L., Kuzma M., Man P., Sadalapure K., Patel A., Bezouška K., Pospíšil M., Petruš L., Lindhorst Th.K., Křen V.

  ChemBioChem, 2004, 5 (4), 445-452

• Regioselective enzymatic acylation of N-acetylhexosamines

  Pavla Simerská, Andrea Pišvejcová, Marek Kuzma, Petr Sedmera, Vladimír Křen, Silvia Nicotra, Sergio Riva

  J. Mol. Catal. B: Enzymatic, 2004, 29, 219–225

• Nitrile Biotransformation by Aspergillus niger

  Šnajdrová R., Mylerová-Kristová V., Crestia D., Nicolaou K., Kuzma M., Lemaire M., Galienne E., Bolte J., Křen V., Martínková L.

  J. Mol. Catal. B: Enzymatic, 2004, 29, 227–232

• Enzymatic synthesis of N- acetylglucosaminobioses by reverse hydrolysis: Characterisation and application of the library of fungal b-N- acetylhexosaminidases

  J. Rauvolfová, L. Weignerová, M. Kuzma, V. Přikrylová, A. Pišvejcová, M. Macková, V. Křen

  J. Mol. Catal. B: Enzymatic, 2004, 29, 259–264

• β-N-Acetylhexosaminidase-catalysed synthesis of non-reducing oligosaccharides

  J. Rauvolfová, M. Kuzma, L. Weignerová, P. Fialová, V. Přikrylová, A. Pišvejcová, M. Macková, V. Křen

  J. Mol. Catal. B: Enzymatic, 2004, 29, 233–239

• Five new derivatives of nonactic and homo-nonactic acids from Streptomyces globisporus

  Tomáš Řezanka, Jaroslav Spížek, Věra Přikrylová, Aleš Prell and Valery M. Dembitsky

  Tetrahedron, 2004, 60, 4781–4787

• Enzymatic synthesis of complex glycosaminotrioses and study of their molecular recognition by hevein domains

  Nuria Aboitiz, F. Javier Canada, Lucie Hušáková, Marek Kuzma, Vladimír Křen, Jesús Jiménez-Barbero

  Org.Biomol.Chem., 2004, 2, 1987–1994

• Generation of an Alpha-L-Rhamnosidase Library and its Application for the Selective Derhamnosylation of Natural Products

  Daniela Monti, Andrea Pišvejcová, Vladimír Křen, Marco Lama, Sergio Riva

  Biotechnology and Bioengeneering, 2004, 87 (6), 763 - 772

• Oxidised derivatives of silybin and their antiradical and antioxidant activity

  Radek Gažák, Alena Svobodová, Jitka Psotová, Petr Sedmera, Věra Přikrylová, Daniela Walterová, Vladimír Křen:

  Bioorg. Med. Chem., 2004, 12 (21), 5677–5687

Publications 2003

• Flavonoidy silymarinu a polynenasycené mastné kyseliny rybízového oleje jako nutraceutikum v prevenci chronických onemocnění

  N. Škottová, J. Ulrichová, V. Křen, J. Urbaníková, V. Šimánek

  Praktický lékař, 2003, 83 (8), 444-450

• Přírodní látky v prevenci onemocnění trávicího traktu

  M. Modrianský, K. Valentová, V. Přikrylová, D. Walterová

  Chemické Listy, 2003, 97, 540 - 547

• Effects of N-acetyl-glucosamine-coated glycodendrimers as biological modulators in the B16F10 melanoma model in vivo

  L. Vannucci, A. Fišerová, K. Sadalapure, T.K. Lindhorst, M. Kuldová, P. Rossmann, O. Horváth, V. Křen, P. Krist, K. Bezouška, M. Luptovcová, F. Mosca, M. Pospíšil

  Int. J. Oncol., 2003, 23, 285-296

• Synthesis of a Precursor of a Lipid A Mimic

  Baráth M., Petrušová M., Bystrický S., Křen V., Petruš L.

  Chem. Pap., 2003, 57, 121-126

• Application of selectively acylated glycosides for the α-D-galactosidase-catalysed synthesis of disaccharides

  P. Simerská, M. Kuzma, A. Pišvejcová, L. Weignerová, M. Macková, S. Riva, V. Křen

  Folia Microbiol., 2003, 48 (3), 329 - 338

• Enzymatic discrimination of GlcNAc and ManNAc-containing disaccharides using β-N-acetylhexosaminidase

  L. Hušáková, E. Herkommerová-Rajnochová, T. Semeňuk, M. Kuzma, J. Rauvolfová, R. Ettrich, K. Bezouška, V. Křen

  Advanced Synthesis and Catalysis, 2003, 345 (6-7), 735-742

• Fungal β-N-acetylhexosaminidases with high β-N-acetylgalactosaminidase activity and their use for syntheis of β-GalNAc-containing oligosaccharides

  L. Weignerová, P. Vavrušková, A. Pišvejcová, J. Thiem, V. Křen

  Carbohydr. Res., 2003, 338, 1003-1008

• Synthesis of p-nitrophenyl 2-acetamido-2-deoxy-β-D-mannopyranoside and 2-acetamido-2-deoxy-α-D-mannopyranoside

  P. Krist, M. Kuzma, I.P. Pelyvas, V. Kren

  Coll. Czechoslov. Chem. Commun., 2003, 68(4), 801-811

• Molecular Characterization of Binding of Calcium and Carbohydrates by an Early Activation Antigen of Lymphocytes CD69

  J. Pavlíček, B. Sopko, R. Ettrich, V. Kopecký, V. Baumruk, P. Novák, K. Havlíčková, M. Vrbacký, L. Martínková, V. Křen, M. Pospíšil, K. Bezouška

  Biochemistry, 2003, 42 (31), 9295-9306

• Synthetic applications of nitrile-converting enzymes

  Martínková L., Mylerová V.

  Curr. Org. Chem., 2003, 7 (13), 1279-1295

• Enzymatic synthesis of carbohydrate ligands for natural killer cells. The way from ligand optimization towards anticancer glycodrugs.

  Křen V.

  Chemical Probes in Biology, 2003, (Schneider M.P., ed.), 379-389, Kluwer, Amsterodam

Publications 2002

• Selective biotransformation of substituted alicyclic nitriles by Rhodococcus equi A4

  L. Martínková;, N. Klempier,M. Preiml, M. Ovesná, M. Kuzma, V. Mylerová, and V. Křen

  Can. J. Chem., 2002, 80, 724-727

• Clusterred ergot alkaloids modulate cell-mediated cytotoxity

  V. Kren, A. Fiserova, L. Weignerova, I. Stibor, P. Halada, V. Prikrylova, P. Sedmera, M. Pospisil

  Bioorganic Medicinal Chemistry, 2002, 10 (2), 415-424

• Biotransformation of alicyclic hydroxynitriles by Rhodococcus equi A4

  L. Martínková, N. Klempier, M. Ovesná, M. Kuzma, P. Sedmera, H. Griengl, V. Křen

  Can. J. Chem., 2002, 80, 724-727

• Nitrile- and amide-converting microbial enzymes: stereo-, regio- and chemoselectivity

  L. Martínková, V. Křen

  Biocatalysis and Biotransformation, 2002, 20 (2), 73-93

• Exploitation of a Library of α-Galactosidases for the Synthesis of Building Blocks for Glyco-polymers

  M. Casali, L. Tarantini, S. Riva, Z. Huňková, L. Weignerová, V. Křen

  Biotechnol. Bioeng., 2002, 77 (1), 105-110

Publications Patents

• Způsob výroby quercetin-3-beta-D-glukopyranosidu za vzniku L-rhamnosy.

  Křen V., Weignerová L., Marhol P.

  Úřad průmyslového vlastnictví, Patents, číslo patent.spisu PV 2009-720, patent č. 302216. Datum podání přihlášky: 30.10.2009, datum udělení patentu: 18.11.2010. MŠMT LC06010, OC08049, MBÚ AV0Z50200510.

• Způsob výroby opticky čistých stereomerů silybinu A a silybinu B

  Křen V., Gažák R., marhol P., Monti D., Riva S.

  Úřad průmyslového vlastnictví, Patents, číslo patent.spisu PV 2009-687, patent č. 302204. Datum podání přihlášky: 21.10.2009, datum udělení patentu: 5.11.2010. LC06010, ME10027, OC09045, GAČR: 303/08/0658, MBÚ AV0Z50200510

• Nutraceutical with effect upon plasma lipids and antioxidative blood capacity

  Cvak L., Krajicek M., Kren V., Simanek V., Skottova N., Ulrichova J., Volny T.

  Czech Pat., Patents, PV 4404-2000, 27.11.2000

• Method for the production of lysergic acid using biotransformation of lysergamide

  Martinkova L., Kren V., Cvak L.

  Czech Pat., Patents, PV-4340-99, 3.12.1999

• Method of enzyme stabilization in the cells

  Hunkova Z., Marecek V., Oubrecht P., Kren V.

  Czech Pat., Patents, PV 47-99, 8.1.1999

• Preparation of iso-globotriose and its derivatives

  Kren V., Weignerova L., Hunkova Z., Riva S.

  Czech Pat., Patents, PV 1217-99, 7.4.1999

• Silybin glycosides and the method of the preparation

  Kren V., Cvak L., Sedmera P., Simanek V., Ulrichova J., Stuchlik J.

  Czech Pat., Patents, No. 287657, 8.11.2000

• Method for induction of ß-N-acetylhexosaminidase in Aspegillus

  Kren V., Hunkova Z.

  Czech Pat., Patents, 281541, 5.9.1996

• New method of preparation of ß-D-O-galactosides of ergot alkaloids.

  Kren V.

  Czech Pat., Patents, No. 281673, 18.3.1997

• New method of production of enzymes ß-glukuronidase/arylsulfatase from gastric liquid of Helix pomatia

  Kren V., Sajdl P., Taborsky O., Pazout J., Raska B.

  Czech Pat., Patents, PV 3657-89, 16.6.1989

• Industrial strain of fungus Claviceps purpurea {Fr.}Tul. for elymoclavine fructoside preparation

  Kren V., Sajdl P., Malinka Z., Bremek J.

  Czech Pat., Patents, 272 562, 28.5.1992

• New method of elymoclavine fructosides cleavage by means of bakers yeast

  Kren V., Flieger M., Sajdl P.

  Czech Pat., Patents, 279475, 28.2.1995

• New method for ergot alkaloid fructosides preparation

  Kren V., Sajdl P., Flieger M., Svatos A.

  Czech Pat., Patents, 280415, 22.11.1995