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Epoxide hydrolases

Single-enantiomer pharmaceuticals are a growing market with an extensive number of chiral intermediates that are needed for their synthesis. Enantiopure epoxides and vicinal diols are versatile building blocks for the synthesis of various biologically active compounds. They can be obtained from inexpensive racemic epoxides using some wild-type or engineered epoxide hydrolases by kinetic resolution or enantioconvergent hydrolysis. Especially interesting are enantioconvergent epoxide hydrolases because in enantioconvergent processes there is no 50% yield limitation, which is linked to any resolution process.

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Institute of Microbiology - Czech Academy of Sciences