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Isoquercitrin (Quercetin-3-β-glucopyranoside), Bioquercetin

Isoquercitrin

Isoquercitrin (Quercetin 3-glucoside)

CAS No.
482–35–9
IUPAC name
2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-oxy-chromen-4-one
Molecular formula
C21H20O12
molecular weight
464.4 g/mol

Quercetin and glycosides

Quercetin, a substance marketed as a food supplement, is present in many plants, but for practical purposes it is derived from rutin (quercetin-3-O-rhamnoglucoside), which is treated with acid to obtain quercetin. Rutin is isolated from the seed pods of the Brazilian shrub “fava d´anta” (Dimorphandra mollis). There is significant evidence in the literature concerning anti-proliferative and cell growth regulating properties of quercetin.

Examples of applications of Isoquercitrin

Health benefits attributed to isoquercitrin and rutin have been associated with improvement of capillary health by strengthening blood vessels, and anti-histamine like benefits. Research has shown that quercetin by itself is poorly absorbed. The Iso form of quercitrin has been shown to provide superior absorption, making it more bioavailable to the body.

Most of these studies were carried out in vitro (cell culture). Quercetin in vivo, however, is poorly resorbed from the gastrointestinal tract. Quercetin has been also identified to have some adverse effects as demonstrated e.g. by the positive Ames’ test (potential mutagen). Fortunately, another form of quercetin, isoquercitrin (quercetin-3-O-glucoside), is much better resorbed due to the carbohydrate portion of the molecule. Its increased resorption, compared to quercetin and rutin, has been amply documented in the literature.

Natural sources of Isoquercitrin

Isoquercitrin (Bioquercetin) is a naturally occurring form of quercetin. It can be found typically in apples, onions and many other fruits and vegetables. It could be considered to be a “bio-quercetin” void of potential adverse effect of quercetin.

Isoquercitrin – technology

Institute of Microbiology, CAS, Prague has developed a proprietary enzymatic technology for a selective hydrolysis of rutin into isoquercitrin. It is very robust a relatively simple technology that is biocompatible, without the use of any harmful chemicals and organic solvents.

Isoquercitrin – specification and licensing

Institute of Microbiology offers the product (isoquercitrin) in two qualities – nutraceutical (min 90 %) and high purity (min 99.5 %). We also offer licensing respective technology including the strain for enzyme production and analytical service.

Product specification (typical)

Nutraceutical Isoquercitrin

Isoquercitrin min. 90 %
Rutin max. 3 %
Quercetin max. 0.5 %
Ash (as sulfate) max. 0.7 %
Heavy metals (as Pb) max. 0.0015 %
Loss of drying max. 7 %
Mycotoxins absent

Yellow fine amorphous powder spray-dried.

High purity Isoquercitrin

Isoquercitrin min. 99.5 %

Traces of rutin and quercetin
Yellow-orange crystals.

Relevant references

Institute of Microbiology - Czech Academy of Sciences